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Consistent with this result, HPL flavonoids with a typical flavonol C6C3C6 carbon framework exhibited stable free radical scavenging activity by interacting with free radicals to form stable adducts and then generating neutral molecules via retro-Diels-Alder degradation ( Under conditions of estrogen deficiency, the macromolecular enzymes that maintain the balance of free radicals in the body exhibit reduced free radical scavenging activities

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[36] Jayaram, L., King, P.T., Hunt, J., Lim, M., Park, C., Hu, E

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[81] have shown a negative correlation of the expression of genes involved in mitochondrial metabolism and HbA 1c , while the expression of genes for enzymes involved in glycolysis was positively correlated with HbA 1c

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We screened candidate mutant lines by PCR and Sanger sequencing and identified the Atg8a 12 allele that carries an 8-bp deletion based on sequencing data (Fig S2A), which causes frameshift in all isoforms of the Atg8a gene

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