Consistent with this result, HPL flavonoids with a typical flavonol C6C3C6 carbon framework exhibited stable free radical scavenging activity by interacting with free radicals to form stable adducts and then generating neutral molecules via retro-Diels-Alder degradation ( Under conditions of estrogen deficiency, the macromolecular enzymes that maintain the balance of free radicals in the body exhibit reduced free radical scavenging activities
[36] Jayaram, L., King, P.T., Hunt, J., Lim, M., Park, C., Hu, E
KhreissTJozsefLHossainSChanJSDPotempaLAFilepJG
[81] have shown a negative correlation of the expression of genes involved in mitochondrial metabolism and HbA 1c , while the expression of genes for enzymes involved in glycolysis was positively correlated with HbA 1c
We screened candidate mutant lines by PCR and Sanger sequencing and identified the Atg8a 12 allele that carries an 8-bp deletion based on sequencing data (Fig S2A), which causes frameshift in all isoforms of the Atg8a gene