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However, ondansetron is well-absorbed from the gastrointestinal tract, and clinically significant effects on its efficacy have not been documented in the literature

It helps regulate appetite + blood sugar levels by slowing digestion, reducing food intake, and enhancing insulin secretion

The sensation you felt after drinking the wine may, or may not, have had anything to do with the B12 but personally I have a tiny (snifter) glass of fortified wine every day without any adverse effect and I'm still " clivealive " and nearly 77 years old Don't forget to get your Folate level checked, Thank you clivealive

They are targeting different mechanisms entirely

The flavors are pretty fun too (Nashville Hot Chicken, anyone?)