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Third , the combination lacks robust safety data from controlled trials, meaning potential synergistic effects or unexpected interactions remain inadequately characterized

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In vitro studies have demonstrated that the GLP-1R in mouse insulinoma 6 cells (MIN6), a pancreatic cell line, is endocytosed upon activation via both clathrin-coateddependent and caveolin-1dependent mechanisms (42)

3.3 Low FODMAP diet FODMAP stands for fermentable oligosaccharides, disaccharides, monosaccharides, and polyols

Monitoring and Adverse Effects Plasma creatinine, alanine, and aspartate transaminases monitored at 2-, 4-, 8-, 12-, and 16-weeks (Figure 1B) did not show any increase compared to baseline values (Table 4)