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Since after development of sitagliptin which was approved by the U.S Food and drug administration (FDA) in 2006, nine DPP4 inhibitors are already available in the market and have shown great efficacy with lower toxicity when compared with existing therapies (Figure 6)

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In particular, we observed that the -1 subcluster expressed low levels of ARX , IRX2 , CRYBA2 , ALDH1A1 , and TM4SF4