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Document the exact timing and consider expanded prenatal screening including cell-free DNA testing at 10 weeks and detailed anatomy evaluation in the second trimester

The mechanism research has produced both basic-science findings on the molecular targets and translational-research observations in disease-model systems

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These physiological perturbations can interact with cardiovascular phenotypes and prothrombotic states to play a significant role in stroke recurrence, functional outcome (Arboix, 2015), and outcome with pharmacological intervention with tissue plasminogen activator (tPA) (Seet et al., 2014)