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Bone morphogenetic proteins (BMPs) are the most representative example, which have been granted US Food and Drug Administration (FDA) approval for clinical applications in recalcitrant long bone non-unions, lumbar fusion and open tibial shaft fractures [1618]

However, this study demonstrated that antioxidant vitamins did not show a statistically significant effect by themselves

Through its interaction with the enzyme glutathione reductase, it constantly shifts between its active and inactive form, ensuring a continuous defense against free radical scavenging