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Based on the letters, compounded GLP-1 drugs are not FDA-approved and cannot be marketed on a large scale once the branded versions are no longer in short supply

Important safety considerations include: tirzepatide is not indicated for type 1 diabetes or treatment of diabetic ketoacidosis, and it is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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In a subsequent set of studies, we subjected isolated cardiomyocytes to either isoproterenol or PAGln (2 M) carvedilol (1 M) and measured cardiomyocyte contraction, calcium transients, and pSer 16 phospholamban (Fig