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Shifting your injection to a day that makes the peak tiredness window less disruptive - a Friday injection means the worst of it falls over the weekend, for example - is a simple practical adjustment that makes a real difference for some people

Ann N Y Acad Sci (2008) 1150:1526

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Methotrexate action in rheumatoid arthritis: stimulation of cytokine inhibitor and inhibition of chemokine production by peripheral blood mononuclear cells