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However, the molecular targets of BH4-mediated direct antioxidant effect remain undefined, and specific research in the hyperglycemic and hypoxic pathological microenvironment of DR is lacking, with the heterogeneous role of BH4 in retinal cells yet to be further elucidated

Once target genes or cytokines are identified, transgenic mice overexpressing candidate gene constructs will be useful for testing whether a gene is sufficient to induce atrophy

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This formulation may include K1 (Phylloquinone), K2 MK-4, or MK-7, depending on the variant, ensuring comprehensive support for calcium regulation and arterial flexibility