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Classification of DILI is based on its clinical presentation (cholestatic, hepatocellular, or mixed), the underlying mechanism of liver damage, or the histological findings observed in a liver biopsy [53]

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(3) Regulation of gut microbiota by RIOS Different types of oligosaccharides exert targeted regulation on gut microbiota: Fructooligosaccharides: promote the increased abundance of Bifidobacterium, Lactobacillus, Faecalibacterium, Ruminococcus, Sutterella , and Oscillospira (118)