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250, 550, and 850 mg/kg of Torreya grandis oil decreased Porphyromonadaceae to 15.57, 10.96, and 6.97%, increased Erysipelotrichaceae to 20.32, 36.55, and 38.75%, and enhanced Coriobacteriaceae to 7.65, 1.94, and 3.07% during their anti-obese effects in high-fat diet-induced mice (88)

As expected, the three best compounds in vivo, 14 , 22 and 23 , had all (1) improved stability in NEP 24.11 degradation assays, (2) prolonged half-lives in mouse plasma and (3) decent potency