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In the KEYNOTE-119 trial, monotherapeutic pembrolizumab did not significantly improve OS in patients with previously treated metastatic TNBC compared to chemotherapy, which might inform future research of pembrolizumab monotherapy for selected patients, specifically those with PD-L1-enriched tumors, and combinatorial approach might be necessary for the treatment of patients with metastatic TNBC

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Tesamorelin: This is an FDA-approved GHRH analog specifically designed to reduce visceral fat in patients with HIV-associated lipodystrophy

In addition to GSTO1, C1-27 showed binding also to PDI

But as metabolic support