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Direct cellular interactions and growth factor modulation: Peptides can interact directly with cell membranes, DNA or proteins to disrupt pathological processes or to deliver therapeutic cargo inside cells

Peptide drugs are mainly eliminated by protease enzymes, while liver uptake is minimal

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Patients who required invasive management (surgery, radiologic or endoscopic intervention) or died from postoperative complication where issued as severe morbidity (grade IIIV) 45