[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Kolberg M., Holand M., Agesen T.H., Brekke H.R., Liestol K., Hall K.S., Mertens F., Picci P., Smeland S., Lothe R.A
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Research demonstrates that acetyl-L-carnitine ameliorates insulin resistance through multiple mechanisms: restoring tissue carnitine levels in skeletal muscle and myocardium, improving mitochondrial -oxidation of fatty acids to reduce accumulation of lipotoxic intermediates, enhancing glucose disposal and oxidation capacity, and reducing inflammatory signaling that impairs insulin receptor function
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