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By globally fitting the data to a 1:1 Langmuir binding model using Biacore Insight software (v6.0), the association and dissociation constants were determined

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144 In a four-week, randomized, placebo-controlled trial in 100 women with menopausal symptoms, psychological symptom scores decreased by 73% in those receiving 1,000 mg evening primrose oil (standardized to provide 70140 mg of GLA) twice daily but were unchanged in those given placebo