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The STEP trials evaluated semaglutide and showed average weight reductions of around 15% over 68 weeks, while SURMOUNT trialsfocusing on tirzepatide, a dual GIP/GLP-1 receptor agonistdemonstrated even greater reductions, with participants losing up to 21% of their body weight over 72 weeks (Note: GIP = Glucose-dependent insulinotropic polypeptide)

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Based on the established method list, PRM data acquisition was performed via the Q Exactive HF-X mass spectrometer, with the MS parameters set identically to those of the previously described proteomics experiments

Only GMP materials will be supplied, logistics all according to GDP

10.1016/S0140-6736(20)30045-3 59 VaziriN