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How to think critically about longevity practices from fasting to peptides

Researchers investigating incretin-based compounds use Retatrutide as a reference molecule when comparing receptor selectivity and downstream signaling effects across the GLP-1/GIP/glucagon receptor family

Fischer J, Degenhardt F, Hofmann A, Redler S, Basmanav FB, Heilmann-Heimbach S, Hanneken S, Giehl KA, Wolff H, Moebus S, Kruse R, Lutz G, Blaumeiser B, Bohm M, Garcia Bartels N, Blume-Peytavi U, Petukhova L, Christiano AM, Nothen MM, Betz RC (2017) Genomewide analysis of copy number variants in alopecia areata in a Central European cohort reveals association with MCHR2

Treatment switchers were identified as patients with records of at least one prescription for injectable semaglutide, and a prescription for any other GLP-1 RA in the 365 days before the earliest semaglutide prescription (baseline period)

Aug 2003;9(3):157-60