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Here, we propose to address these limitations by developing a new model of opioid self-administration using head-fixed mice

GLP-1 (Glucagon-like peptide-1) is one such peptide, released by the intestine, which helps prime insulin release, thus allowing the body to absorb glucose after a meal

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\n\n\n\n The compounds multimechanistic nature also makes it challenging to evaluate through conventional clinical trial frameworks, which are typically designed around single-mechanism drugs with well-defined target receptors and predictable dose-response relationships