Exenatide (EXE) (2 mg weekly), Dapagliflozin (DAPA) (10 mg daily), Exenatide + Dapagliflozin (2 mg weekly/10 mg daily), Dapagliflozin (10 mg) + Metformin (MET) (2000 mg extended release daily), or Phentermine (7.5 mg)/Topiramate were given to the patients for 24 weeks (46 mg extended release daily)
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When combined, the risk of serotonin syndrome, a potentially life-threatening condition, increases, as both medications can influence serotonin levels in the brain. Serotonin might be the bodys feel good chemical, but serotonin syndrome may cause nausea, vomiting, diarrhea, and tremors when its mild or high blood pressure, racing heart rate, seizures, and fainting when its more severe
Classical Wnt signaling involves the interaction of lipid-modified Wnt, through a series of biochemical reactions, resulting in elevated nuclear -catenin levels, ultimately activating Wnt-mediated signaling (Schmiege and Li, 2024)
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