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In response, enteroendocrine cells upregulate GLP-1 secretion, and GLP-1 receptor activation has been shown to suppress pro-inflammatory cytokines and macrophage infiltration

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Potential desensitization

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523 Analysis of gene expression in cortical astrocytes from old mice identified an increase in genes linked to an immune response with a decrease in expression of GFAP and genes related to neuroprotection and neuronal support, 524 and the prominent up-regulation of genes contributing to synapse elimination in astrocytes from aged hippocampus and cerebellum