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However, it remains uncertain whether these observations reflect direct modulation of aging-related mitochondrial decline or secondary improvements resulting from restored metabolic homeostasis

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In summary, although the two neurons did not die of GPX4 reduction, the study focused on only one point of GPX4 and did not delve into other regulators, indicating that there are other pathways affecting the activity of POMC neurons under obesity conditions (129)

The connection lies in the metabolic environment that may promote both conditions independently

Higher testosterone levels can lead to an increase in sperm count and motility, which are critical factors for successful fertilization