The rationale for this strategy is based on a randomized trial of 40 patients with mild-to-moderate acne who were assigned to receive isotretinoin alone or isotretinoin plus desloratadine 1
It activates phase 2 enzymes by signaling through nuclear factor erythroid 2related factor 2 (Nrf-2) and interacting with the Keap1 protein
doi: 10.1016/j.biopha.2024.116547 208 DoddDSpitzerMHVan TreurenWMerrillBDHryckowianAJHigginbottomSKet al
It reduced pro-inflammatory cytokines (TNF-, IL-6, IL-1), chemokines, adhesion molecules and oxidative stress, while upregulating the expression of neurotrophic factors (neuritin and NGF) [11]
These filings remain allegation-based, and the litigation process is designed to test what the evidence shows about risk, labeling, and causation for individual patients who report severe gastrointestinal disease and related complications such as severe abdominal pain and ongoing digestive dysfunction