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GLP-1 agonists reduce appetite, modulate satiety circuits, alter hepatic lipid handling, improve endothelial function, attenuate inflammatory tone, influence microglial behavior, and appear to exert downstream neuroprotective effects, yet the field cannot convincingly articulate how these effects relate to one another, which are primary versus secondary, or which are merely correlative epiphenomena arising from broader systemic shifts

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Before GLP-1 use, the majority of participants reported being non-smokers (56.4%), which remained unchanged after GLP-1 use

A 20 mg tirzepatide vial with 1 mL of bacteriostatic water makes 20 mg/mL, where 10 mg draws 50 units and 15 mg draws 75 units