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On the safety side, centella and its triterpenes are classified as weak sensitizers, meaning allergic reactions are possible but uncommon

Sherr CJ, Kato J, Quelle DE, Matsuoka M, Roussel MF

Strengthen pharmacovigilance to detect any brand-specific issues early

Dysfunctions of AFG3L2 have been linked to neurodegenerative diseases such as dominant optic atrophy 33 and PINK1-mediated mitochondrial fission 34 , though its role in cancer remains under-investigated

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