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Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes

Postmortem and imaging studies have revealed electron transport chain defects and impaired pyruvate dehydrogenase activity in ASD brains, with regional reductions in Complex I availability and non-ETC enzymes such as aconitase and PDH

Angewandte Chemie, 132 (49), 2241422421

Pathological changes caused by myocardial ischemia, such as intracellular acidification, glycolysis, and increased ROS production, can promote the lipid peroxidation process