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Int J Cancer 124(11):25492558

Although so far there are no drugs approved by the Food and Drug Administration for TBIs pharmacological treatment, numerous pharmaceutical compounds have been studied to help patients

In contrast, J147, operates with nanomolar potency (EC50 = 25nM) by directly inhibiting mitochondrial ATP synthase (ATP5A) and activating the AMPK/mTOR pathway [268, 270]