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While the active ingredient remains unchanged, the preparation process differs from commercially manufactured options and allows dosing to be aligned with individualized clinical plans

As a result, T cells may be activated, increasing CD95L+ cells/mononuclear cells in the LP and epithelium

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Earlier concerns regarding acute pancreatitis and pancreatic cancer have largely been alleviated by long-term randomized trials that have not confirmed a causal association, although reporting biases and diagnostic complexity remain considerations, and continued pharmacovigilance is recommended