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Autophagy induction can be triggered by diverse cellular signals, such as nutrient deprivation, OS, infection, or the accumulation of misfolded proteins

doi: 10.1016/j.jad.2025.119670 5 LiJ-RCaoJWeiJGengW

However, this persistent effect also means tirzepatide may reduce the adaptive metabolic response that intermittent fasting traditionally triggers, potentially limiting some of fasting's cellular benefits like autophagy activation

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