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Yuan, W
Endocrinology (2005) 146(12):527886.10.1210/en.2005-0939 257 FanYMenonRKCohenPHwangDClemensTDiGirolamoDJet alLiver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism
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The triple-agonist mechanism, particularly the glucagon component driving preferential fat oxidation, appears to shift the ratio toward greater fat selectivity
In contrast, after cessation, prior use of GLP-1RAs is associated with a higher risk than prior use of DPP4is or SGLT2is
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