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Vasoconstriction is caused by noradrenaline activated alpha-1 adrenergic receptor released from sympathetic ganglion neurons

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In line with only marginally attenuated DIO of male and female PAR2-R38E mice, postprandial gut hormone levels were not different from those in obese PAR2-WT mice (Figure 3, G and H)

This inefficiency means you need to take significantly higher doses to achieve therapeutic levels in your blood, which can be both costly and ineffective