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Symptomatologic improvement was greater in patients younger than 6 years of age as compared to those who began supplementation at an older age, though, this study was a case series of 20 patients, further randomized controlled trials are needed

Current interventions are predominantly confined to animal model validation, with limited clinical translation due to several challenges: inadequate molecular targeting efficiency, suboptimal delivery system performance, and unresolved multi-target synergistic mechanisms

IGF-1 LR3: Slightly Reduced but Sustained IGF-1R Engagement IGF-1 LR3, by contrast, has slightly reduced intrinsic affinity for IGF-1R compared to native IGF-1

Safety of antioxidant vitamins and beta-carotene