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NAD+ (nicotinamide adenine dinucleotide) is a naturally occurring molecule found in every cell and plays an essential role in energy metabolism and cellular function

Originally developed for type-2 diabetes, drugs such as semaglutide (Ozempic, Wegovy) from Novo Nordisk and tirzepatide (Mounjaro, Zepbound) from Eli Lilly and Company have become synonymous with modern pharmacologic weight management

Creatinine is an important marker but always interpreted alongside other tests

The amino acid contents except for alanine and lysine all declined (Additional file 7: Table S7)