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Persistent vomiting or diarrhea: If you can't keep fluids down for more than 24 hours or have severe diarrhea, you risk dehydration and need medical evaluation

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For people with insulin resistance or elevated blood sugar, tirzepatide can bring glucose levels down meaningfully and quickly

What if tirzepatide side effects are too severe to continue

Mounjaro Side Effects: What to Expect and How to Prevent Them Written by: Morgan Pennington , 12 Feb 2026 27 min read Reviewed and fact-checked: Ayesha Bashir , Prescribing Pharmacist, 12 Feb 2026 Like any medication, Mounjaro can cause side effects , but most people find they are mild, manageable, and settle as the body adjusts