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Because of saturable absorption, an oral loading dose, such as 20 mg/kg, should be divided into four equal doses and given at 6-hour intervals

A method for synthesizing semaglutide is characterized in that ionic liquid is used as a hydrophilic Linker to be coupled to solid-phase resin, then the ionic liquid is sequentially connected with corresponding amino acids in a semaglutide sequence through a solid-phase synthesis method, and the semaglutide fine peptide is obtained through cracking and purification

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These can lead to dehydration, which may affect blood pressure readings and kidney function