This condition primarily arises from an imbalance between muscle protein synthesis and degradation, alongside reduced force-generating capacity, often secondary to neuropathy, myofibrillar disruption, sarcoplasmic reticulum (SR) impairment, altered excitability and mitochondrial dysfunction (68)
95% CI, 0.37-0.83)
Here, a question also arises as to whether this effect of GLP-1 receptor agonists is associated with an individuals genetic makeup and if a genetic tendency to gain weight affects the intensity of response of the drugs in alcoholics
These include larger registration studies such as ATTAIN-HYPERTENSION and smaller studies to evaluate blood pressure alongside weight loss, such as SOLUTION-Pilot
Liraglutide is a human GLP-1 derivative, which is characterized by the retention of unaltered Ala at position 8, and structural modifications of amino acids at position 26 and 34 (Gong et al., 2024)