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Compared with active drugs, oral semaglutide was superior to empagliflozin in reducing total cholesterol and LDL [36] and was superior to sitagliptin in reducing total cholesterol, LDL, and TAGs [37, 41], but there was no significant difference when compared with another GLP-1 analogue (liraglutide) [38]

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Individuals interested in GLP-1 receptor agonists should consult a doctor to determine if these medications are a suitable option

28 They found that GLP-1 RA use was associated with a lower risk of incident glaucoma (hazard ratio [HR] = .81), with the risk decreasing even further when GLP-1 RAs were used for longer than 3 years (HR = .71)

For those who require maximal weight loss, such as people managing severe obesity alongside cardiovascular risk or obstructive sleep apnoea, injectable therapy may remain the medically preferred route