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Sample preparation Extraction and quantification of free carnitine and acylcarnitines from the DBS cards were done using a NeoMass AAAC kit (Labsystems Diagnostics Oy, Vantaa, Finland) according to the manufacturers instructions

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It is well-recognized that the PK and exposure-response relationships of drugs can differ widely between children and adults ( Table 1 displays the difference in the median weight from cohort A to cohorts B/C