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Such interactions create crosstalk between epigenetic layers: MeCP2, a methyl-DNA binding protein, can recruit histone modifiers, while histone acetylation status influences DNA methyltransferase access to chromatin 181,182

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Early calculation of the anion gap can narrow the differential diagnosis of patients with metabolic acidosis and measurement of 5-oxoproline can explain acidosis due the interaction of paracetamol and flucloxacillin