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The question of whether Ozempic can be safely used in patients with Crohn's disease requires careful consideration, as there is no official contraindication listed in the Summary of Product Characteristics (SmPC) specifically for inflammatory bowel disease

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Common descriptions include the ability to go longer between meals without thinking about food, reduced interest in previously tempting foods, and increased capacity to stop eating when satisfied rather than when uncomfortably full

This antinociceptive profile may reflect DSIPs interaction with endogenous opioid peptide systems and/or NMDA receptor modulation at spinal cord and supraspinal pain processing sites