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The long-term use of certain peptide preparations led to significantly increased longevity (mean lifespan increases between 20% and 40%) as well as a slower rate of age-associated alterations to biomarkers linked to physical and mental decline

RCT evidence: A: Robust replicated results from at least 2 large long-term double-blind RCT, ideally with confirmation from a systematic review or meta-analysis B: Supporting evidence from the primary outcome of at least one large long-term double-blind RCT C: A lack of supporting evidence from the primary outcome of a large long-term double-blind RCT but promising results from either small pilot RCTs or from post-hoc and planned secondary analyses

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