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GLP-1 RAs were initially approved for the treatment of type 2 diabetes mellitus (T2DM)

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The biochemistry behind this process involves testosterone conversion through a specific enzyme

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This dependence on G6PD activity in activated T cells occurs despite the partially redundant contribution of other enzymes like isocitrate dehydrogenase and malate dehydrogenase to the overall production of cellular NADPH, which is needed for biosynthesis of immune effector molecules ( Figure 1A-3 )