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For heart failure, GLP-1RAs remodel calcium circulation disorders, inhibit cardiac hypertrophy by activating the AMPK/ mTOR signaling pathway and attenuate methylglyoxal-induced mitochondrial abnormalities

Seiwerth and colleagues (Inflammopharmacology, 1999) documented effects on angiogenic growth factor pathway signalling, and subsequent work has expanded characterisation to include VEGF receptor 2 upregulation, endothelial cell migration in capillary-formation assays, and improved healing in ischemia-reperfusion preparations

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[Abstract] Int J Neuropsychopharmacol