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Managing GI Side Effects# Regardless of the specific drug, several strategies can mitigate GI adverse events: Slow titration: Following or extending the recommended dose escalation schedule Dietary modification: Smaller meals, avoiding high-fat foods, eating slowly Timing: Taking the injection (or pill) at a consistent time, often in the evening Hydration: Maintaining adequate fluid intake to offset effects of reduced food intake Anti-emetics: Short-term use during dose escalation if needed What to Watch# Ecnoglutide and CT-388 Phase 3 data -- Will the tolerability advantage of biased agonism hold in larger, longer trials

& Giugliano, D

Weight regain after stopping Zepbound is not a treatment failure but rather reflects the chronic nature of obesity as a disease

But I also wonder what would have happened if I had reached for a medication before giving myself time to build a lifestyle that supported the weight I wanted to maintain

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