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After cleaning duplicate entries, disproportionality measures (reporting odds ratio (ROR), proportional reporting ratio (PRR), and relative reporting ratio (RRR)) were calculated, with Evans criteria applied to assess signal significance

While people expect something simple, they get instead of variation, and that variation can make them think something is wrong when everything is going exactly as it should

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Study populations, inclusion criteria, trial duration, comparator design, and development-stage context all limit how broadly findings can be interpreted