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Formation of the NFT radical anion by cellular reductases To elucidate the mechanism of Nrf2 activation by NFT, we focused on the ability of NFT to yield an activated species capable of oxidizing critical sulfhydryl groups in the Nrf2-Keap1 complex

The fetal liver exhibited higher mitochondrial activity and increased mitochondrial DNA copy numbersboth indicative of enhanced energy metabolismwithout major shifts in gene expression, suggesting that regulation may occur at the protein level (Safain et al., 2025)

[8] Li Z, Zhang J, Wu Y, et al

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[8] Third, short-term calorie restriction, defined as a 30% reduction in caloric intake for two weeks, which naturally increases ghrelin levels and thus activates the receptor, was found to increase both performance on spatial learning tasks as well as neurogenesis in the adult hippocampus