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Brister D, Rose S, Delhey L, Tippett M, Jin Y, Gu H, Frye R

Agents Linaclotide [5] Peptide agonist of guanylate cyclase-C Increases intestinal secretion of bicarbonate, chloride, and fluid, which improves fecal transit Lubiprostone [5] Prostaglandin derivative that activates chloride channels on the apical surfaces of enterocytes Increases intestinal fluid secretion and improves fecal transit Plecanatide [22] A guanylate cyclase-C agonist Increases intestinal secretion of bicarbonate, chloride, and fluid, which improves fecal transit Adverse effects Special patient groups Constipation in infants, children, and adolescents is detailed separately

Promote satiety: They act on appetite-regulating centres in the brain to increase the feeling of fullness after eating

Octreotide scintigraphy (Octreoscan) performed before relacorilant treatment was positive for a lung lesion, but a CT scan and MRI of the lungs did not show any discrete mass at study entry

(PubMed) Hassan I, Chibber S, Khan AA, Naseem I