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Prmt1 upregulated by Hdc deficiency aggravates acute myocardial infarction via netosis

This makes it particularly valuable for autoimmune and chronic inflammatory conditions

About 20-30% of patients have minimal or no side effects

The final step in establishing preclinical proof-of-hypothesis was made when the results of these acute studies were recapitulated with chronic dosing, showing that the beneficial pancreatic islet and glucose-lowering effects of DPP-4 inhibition persisted over several months of treatment (30, 31)