Weekly semaglutide 2.4 mg (Wegovy, Novo Nordisk), a GLP-1 receptor agonist, is the first-approved drug for chronic weight management in adults with general obesity or overweight since 2014
But the work doesn't stop, now we have to maintain that goal without the help of medication
High cardiovascular risk: Patients with multiple risk factors (diabetes, hypertension, high cholesterol, smoking history, family history) likely benefit, though direct trial evidence in lower-risk populations is less extensive
Pituitary adenomas (Cushing's disease) are usually managed with trans-sphenoidal surgery as first-line treatment
This real-world evidence provides a validation of the oral semaglutide data used in the present analysis taken from PIONEER 4, but could not be used to inform a full analysis, as no liraglutide arm was included and use of these treatment effects in a different baseline population is potentially inappropriate