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The oral form, in particular, may have a higher incidence of gastrointestinal side effects due to its daily dosing and direct contact with the digestive tract

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Bisubstrate inhibitors such as NS1, LL320, and II399 based on adenosyl scaffolds have shown promise in this regard 199,200,201

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Chen K, Chen L, Shan Z, et al

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Stopping or interrupting GLP-1s for 6 months or more raised the risk for adverse cardiovascular events

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That mismatch, plus safety history, is why research blends overwhelmingly use no-DAC

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