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In this survey, more patients said that they would prefer a treatment with a profile similar to empagliflozin (41%) or sitagliptin (31%) than to oral semaglutide (11%), with factors such as the need for fasting and potential for adverse gastrointestinal effects influencing their decisions [89]

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These findings underscore the multifaceted roles of DPP-4, not only as an osteoclast-derived protein but also as a connector between bone remodeling and energy metabolism, with significant implications for the pancreatic-endocrine-bone axis [3, 36, 37]